Aspirin Linked With Increased Risk of Heart Failure in New Study


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Aspirin usage is connected with a 26% raised threat of cardiac arrest in individuals with a minimum of one inclining aspect for the condition. That’s the finding of a research study released today (November 22, 2021) in ESC Heart Failure, a journal of the European Society of Cardiology (ESC). Predisposing aspects consisted of smoking cigarettes, weight problems, hypertension, high cholesterol, diabetes, and heart disease.

“This is the first study to report that among individuals with a least one risk factor for heart failure, those taking aspirin were more likely to subsequently develop the condition than those not using the medication,” stated research study authorDr Blerim Mujaj of the University of Freiburg,Germany “While the findings require confirmation, they do indicate that the potential link between aspirin and heart failure needs to be clarified.”

The impact of aspirin on cardiac arrest is questionable. This research study intended to examine its relationship with cardiac arrest occurrence in individuals with and without heart problem and examine whether utilizing the drug is connected to a brand-new cardiac arrest medical diagnosis in those at threat.

The analysis consisted of 30,827 people at threat for establishing cardiac arrest who were registered from Western Europe and the United States into the tribute research study. “At risk” was specified as one or more of the following: smoking cigarettes, weight problems, hypertension, high cholesterol, diabetes, and heart disease. Participants were aged 40 years and above and without cardiac arrest at standard. Aspirin usage was tape-recorded at enrolment and individuals were categorized as users or non-users. Participants were followed up for the very first occurrence of deadly or non-fatal cardiac arrest needing hospitalization.

The typical age of individuals was 67 years and 34% were females. At standard, an overall of 7,698 individuals (25%) were taking aspirin. During the 5.3-year follow-up, 1,330 individuals established cardiac arrest.

The detectives evaluated the association in between aspirin usage and occurrence cardiac arrest after changing for sex, age, body mass index, smoking cigarettes, alcohol usage, high blood pressure, heart rate, blood cholesterol, creatinine, high blood pressure, diabetes, heart disease, and treatment with renin-angiotensin-aldosterone-system inhibitors, calcium channel blockers, diuretics, beta-blockers, and lipid-lowering drugs. Taking aspirin was individually connected with a 26% raised threat of a brand-new cardiac arrest medical diagnosis.

To examine the consistency of the outcomes, the scientists duplicated the analysis after matching aspirin users and non-users for cardiac arrest threat aspects. In this matched analysis, aspirin was connected with a 26% raised threat of a brand-new cardiac arrest medical diagnosis. To examine the outcomes even more, the analysis was duplicated after leaving out clients with a history of heart disease. In 22,690 individuals (74%) without heart disease, aspirin usage was connected with a 27% increased threat of occurrence cardiac arrest.

Dr Mujaj stated: “This was the first large study to investigate the relationship between aspirin use and incident heart failure in individuals with and without heart disease and at least one risk factor. Aspirin is commonly used – in our study one in four participants were taking the medication. In this population, aspirin use was associated with incident heart failure, independent of other risk factors.”

He concluded: “Large multinational randomized trials in adults at risk for heart failure are needed to verify these results. Until then, our observations suggest that aspirin should be prescribed with caution in those with heart failure or with risk factors for the condition.”

Reference: “Aspirin use is associated with increased risk for incident heart failure: a patient-level pooled-analysis” by Mujaj B, Zhang ZY, Yang WY, et al., 22 November 2021, ESC Heart Failure
DOI: 10.1002/ ehf2.13688

Funding: The European Union (HEALTH-F7-305507 TRIBUTE), the European Research Council (Advanced Researcher Grant 2011-294713- EPLORE, the European Research Council Proof- of-Concept Grant 713601- uPROPHET), and the European Research Area Net for Cardiovascular Diseases (JTC2017-046- PROACT) supported the Research Unit Hypertension and CardiovascularResearch The Non-Profit Association Alliance for the Promotion of Preventive Medicine (APPREMED; URL,, Mechelen, Belgium, got a nonbinding grant from OMRON Healthcare, Co, Ltd, Kyoto,Japan The sponsors had no function in the preparation of this report.

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