Breakthrough Treatment for Autism Spectrum Disorder Within Reach: Scientists Discover Key Clue

Brain Activity Excited Nerve Cells Illustration

Revealed: The Secrets our Clients Used to Earn $3 Billion

In research study that might result in a basic treatment of autism spectrum condition, researchers have actually recognized the cell-specific molecular network of the developmental special needs.

Scientists in South Korea have actually been successful in determining the cell-specific molecular network of autism spectrum condition. It is anticipated to lay the structure for dealing with autism spectrum condition. Published in the journal Molecular Psychiatry, the research study was performed by Professor Kim Min- sik’s group of scientists at the Department of New Biology, DGIST (Daegu Gyeongbuk Institute of Science and Technology).

Autism spectrum condition is a developmental special needs that is understood to happen from early youth. It is a neuro-developmental condition identified by constant problems of social interaction and interaction-related habits causing minimal varieties of behavioral patterns, interests, and activities, along with repeated habits.

Most autism spectrum condition clients have behavioral conditions, in some cases accompanied by other developmental specials needs. Because there is presently no precise molecular medical diagnosis technique, early medical diagnosis of autism spectrum condition is made at a relatively late duration. Although there has actually been some success in enhancing signs with behavioral management treatment, there is an absence of reliable treatments at the molecular level.

Professor Kim Min- sik’s group made use of the Cntnap2 flaw design, a spectral condition mouse design developed by Professor Lee Yong-Seok’s group at Seoul National University College of Medicine to draw out prefrontal cortex tissue and carried out mass spectrometry-based incorporated quantitative proteomic and metabolomic analysis. In addition, by comparing and examining this with formerly reported huge information of autism spectrum condition clients, the group validated that issues happen in networks such as metabolic process and synapses in excitable nerve cells.

Professor Kim Min- sik of the Department of New Biology stated, “The multi-omics integrated analysis technology developed through this study has advanced the pathological understanding of autism spectrum disorder and made it possible to discover an integrated network ranging from molecular-level cell differentiation induced by a specific autism gene to biometric information,“ and added, “We are trying to find the core network of autism spectrum disorder and discover treatment targets by conducting an integrated analysis of various models.”

Reference: “Cntnap2-dependent molecular networks in autism spectrum disorder revealed through an integrative multi-omics analysis” by Wooyoung Eric Jang, Ji Hwan Park, Gaeun Park, Geul Bang, Chan Hyun Na, Jin Young Kim, Kwang-Youl Kim, Kwang Pyo Kim, Chan Young Shin, Joon-Yong An, Yong-Seok Lee and Min-Sik Kim, 17 October 2022, Molecular Psychiatry
DOI: 10.1038/ s41380-022-01822 -1

This research study was performed with assistance from the Brain Science Source Technology Development Project of the Ministry of Science and ICT.