How a Standard Blood Test Could Save Your Life

Human Heart Attack

Revealed: The Secrets our Clients Used to Earn $3 Billion

Researchers have developed a novel methodology to foretell imminent coronary heart assaults utilizing normal blood assessments and an internet software. Led by Professor Johan Sundström, the research analyzed blood samples from over 169,000 people, discovering 90 molecules linked to coronary heart assault threat. This development gives a singular alternative for people to evaluate their coronary heart assault threat and should considerably improve preventive healthcare efforts.

By analyzing the outcomes of a routine blood take a look at with an internet software, you possibly can decide your elevated threat of experiencing a coronary heart assault within the subsequent six months. This software was created by researchers at Uppsala University with the target of enhancing people’ drive to undertake more healthy life-style habits.

Heart assaults are the most typical reason for loss of life on the planet and are rising globally. Many high-risk persons are not recognized or don’t take their preventive therapy. Now researchers led by Professor Johan Sundström at Uppsala University have discovered that coronary heart assaults may be predicted with a typical blood take a look at. The drawback, in keeping with the researchers, is that threat elements have beforehand been verified in research involving 5 to 10 years of follow-up, the place solely elements which are secure over time may be recognized.

The Dynamic Period Before a Heart Attack

“However, we know that the time just before a heart attack is very dynamic. For example, the risk of a heart attack doubles during the month after a divorce, and the risk of a fatal heart event is five times as high during the week after a cancer diagnosis,” says Sundström, who’s a heart specialist and professor of epidemiology at Uppsala University.

Johan Sundström

Johan Sundström, heart specialist and professor of epidemiology at Uppsala University. Credit: Mikael Wallerstedt

Together with different European researchers, he has proceeded from the speculation that a number of necessary organic processes are lively in the course of the months earlier than a coronary heart assault and that these could possibly be detected utilizing a easy blood take a look at.

“We wanted to develop methods that would enable the health services to identify people who will soon suffer their first heart attack,” Sundström says.

The analysis group had entry to blood samples from 169,053 people with out prior heart problems in six European cohorts. Within six months, 420 of those folks suffered their first coronary heart assault. Their blood was then in contrast with blood from 1,598 wholesome members of the cohorts.

“We identified around 90 molecules that were linked to a risk of a first heart attack. However, the samples that are already taken in healthcare now are enough to predict the risk. We hope that this will increase people’s motivation to take their preventive medicine or stop smoking, for example,” says Sundström.

A Simple Online Tool for Risk Assessment

The researchers have additionally developed a easy on-line software by which anybody can discover out their threat of getting a coronary heart assault inside six months.

“This was one of the aims of the entire study, since we know that people feel relatively low motivation to follow preventive treatments. If you find out that you happen to have an increased risk of suffering a heart attack soon, perhaps you will feel more motivated to prevent it,” Sundström says.

The researchers will now research the 90 or so new molecules to know them higher and see whether or not there are any prospects of therapy.

“We hope to be able to carry out a new study here in Uppsala to see whether the online tool provides the kind of motivation we intend,” Sundström concludes.

Reference: “Markers of imminent myocardial infarction” by Stefan Gustafsson, Erik Lampa, Karin Jensevik Eriksson, Adam S. Butterworth, Sölve Elmståhl, Gunnar Engström, Kristian Hveem, Mattias Johansson, Arnulf Langhammer, Lars Lind, Kristi Läll, Giovanna Masala, Andres Metspalu, Conchi Moreno-Iribas, Peter M. Nilsson, Markus Perola, Birgit Simell, Hemmo Sipsma, Bjørn Olav Åsvold, Erik Ingelsson, Ulf Hammar, Andrea Ganna, Bodil Svennblad, Tove Fall and Johan Sundström, 12 February 2024, Nature Cardiovascular Research.
DOI: 10.1038/s44161-024-00422-2

The research was funded by Hjärt-Lungfonden, Vetenskapsrådet, AFA Försäkring, and Anders Wiklöf.

One of the six cohorts is from the Uppsala-based inhabitants research EpiHealth.