How Serotonin, Dopamine, and the Smell of Food Affect Aging

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Attractive meals smells are sufficient to blunt the life-extending impact of a restricted weight-reduction plan. A analysis staff found out why that is the case and whether or not the phenomenon might be blocked with a drug.

The odor of meals blocks the life-extending impact of a restricted weight-reduction plan. These medication could unblock it.

A analysis research utilizing worms gives new clues in regards to the position of serotonin and dopamine in ageing.

It’s frequent information {that a} nutritious diet is crucial to a wholesome life. And whereas many individuals observe specialised diets to trim down or enhance their total well being, scientists inquisitive about ageing have been actively learning the life-extending results of dietary restriction and fasting.

“There’s a concept called hormesis in biology, the idea of which is what doesn’t kill you makes you stronger,” stated Scott Leiser, Ph.D., an assistant professor in Molecular & Integrative Physiology, and Internal Medicine at University of Michigan Medical School.

“One of the stresses that’s been most studied is dietary restriction, shown in many different organisms to extend lifespan and in people to improve health.”

However, as anybody on a strict weight reduction routine can attest, the mere odor of scrumptious meals will be sufficient to interrupt one’s willpower. What’s extra, earlier analysis really discovered that in fruit flies, engaging meals smells are sufficient to blunt the life-extending impact of a restricted weight-reduction plan. That research was from Leiser’s colleague Scott Pletcher, Ph.D., additionally of the Department of Molecular & Integrative Physiology.

In a brand new research revealed on June 7, 2022, in Nature Communications, Leiser, first authors Hillary Miller, Ph.D., and Shijiao Huang, Ph.D., and their team build on that research to figure out why this is the case and whether a drug could block the phenomenon.

In the roundworm C. elegans, lifespan extension in response to environmental stressors such as dietary restriction involves the activation of the fmo-2 gene. The researchers used the transparent nature of C. elegans to be able to see, in real time, the levels of FMO proteins.

When worms were limited in the amount of food they could eat, the FMO protein, which was highlighted using a fluorescent marker, lit up “like a Christmas tree…it was bright red,” noted Leiser. However, when the worms were exposed to food smells, there was considerably less activation of FMO, leading to a loss of life extension.

One of the main issues of dietary restriction as a potential approach for life extension in people is how difficult it is. But, said Leiser, “what if you could give yourself a drug that confused your body into thinking you were restricting your diet?”

Building on earlier research showing that neurotransmitters regulate longevity resulting from dietary restriction, the team screened compounds known to act on neurons.

They found three compounds that could prevent the reversal of fmo-2 induction in the presence of food: an antidepressant that blocks the neurotransmitter serotonin, and two antipsychotic drugs used to treat schizophrenia, both of which block the neurotransmitter dopamine.

“We know serotonin and dopamine are major players in the reward portion of the brain and tend to be involved in satiety and food response signals,” said Leiser. “The fact that the drugs we found were antagonizing this suggests you are blocking aspects of these pathways.” Ultimately, the drugs enabled the life extension effect of FMO, even in the presence of the smell of food.

These specific drugs are unlikely to be prescribed for this effect however, given their many potentially dangerous side effects. But they provide important clues about the fmo-2 activation pathway and its effect on life extension.

Reference: “Serotonin and dopamine modulate aging in response to food odor and availability” by Hillary A. Miller, Shijiao Huang, Elizabeth S. Dean, Megan L. Schaller, Angela M. Tuckowski, Allyson S. Munneke, Safa Beydoun, Scott D. Pletcher and Scott F. Leiser, 7 June 2022, Nature Communications.
DOI: 10.1038/s41467-022-30869-5

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