Lack of microRNA Molecule in Red Blood Cells Causes Vascular Damage in Type 2 Diabetes

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Red Blood Cells Flow in Blood Vessel

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Altered function of the red cell results in vascular damage in type 2 diabetes. Results from a brand-new research study in cells from clients with type 2 diabetes and mice reveal that this result is triggered by low levels of an essential particle at a loss blood cells. The research study by scientists at Karolinska Institutet in Sweden has actually been released in the journal Diabetes

It is popular that clients with type 2 diabetes have actually an increased threat of heart disease. Over time type 2 diabetes might harm capillary, which might cause lethal issues such as cardiovascular disease and stroke. However, the illness systems underlying cardiovascular injury in type 2 diabetes are mostly unidentified and there is presently an absence of treatments to avoid such injuries.

In current years, research study has actually revealed that the red cell, whose crucial task is to transfer oxygen to physical organs, end up being inefficient in type 2 diabetes and can serve as conciliators of vascular issues. In the existing research study, scientists at Karolinska Institutet have in cells from clients with type 2 diabetes and mice analyzed which molecular modifications at a loss blood cells might discuss these hazardous results in type 2 diabetes.

The scientists discovered that levels of the little particle microRNA-210 were significantly decreased in red cell from 36 clients with type 2 diabetes compared to red cell of 32 healthy topics. Micro- RNAs come from a group of particles that work as regulators of vascular function in diabetes and other conditions. The decrease in microRNA-210 triggered changes in particular vascular protein levels, and impaired capillary endothelial cell function. In lab experiments, remediation of microRNA-210 levels in red cell avoided the advancement of vascular injury through particular molecular modifications.

“The findings demonstrate a previously unrecognized cause of vascular injury in type 2 diabetes,” states Zhichao Zhou, scientist at the Department of Medicine, Solna, Karolinska Institutet, who carried out the research study in cooperation with to name a few Professor John Pernow at the very same department. “We hope that the results will pave the way for new therapies that increase red blood cell microRNA-210 levels and thereby prevent vascular injury in patients with type 2 diabetes.”

Reference: “Downregulation of erythrocyte miR-210 induces endothelial dysfunction in type 2 diabetes” by Zhichao Zhou, Aida Collado, Changyan Sun, Yahor Tratsiakovich, Ali Mahdi, Hanna Winter, Ekaterina Chernogubova, Till Seime, Sampath Narayanan, Tong Jiao, Hong Jin, Michael Alvarsson, Xiaowei Zheng, Jiangning Yang, MD, Ulf Hedin, Sergiu-Bogdan Catrina, Lars Maegdefessel and John Pernow, 9 November 2021, Diabetes
DOI: 10.2337/ db21-0093

The research study was funded by the Swedish Research Council, the Swedish Heart and Lung Foundation, the Diabetes Research Wellness Foundation, the Stockholm County Council ALF, the EFSD/Sanofi European Diabetes Research Programme in Macrovascular Complications, the Loo and Hans Ostermans Foundation, Karolinska Institutet, the Sigurd and Elsa Goljes Memorial Foundation, the Lars Hiertas Memorial Foundation, the von Kantzow Foundation and the Konung Gustaf V: s och Drottning Victorias Frimurarestifelse.