Large, Red, Itchy or Painful Skin Reactions to Moderna COVID-19 Vaccine in Some Patients

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Skin Reaction to Moderna COVID-19 Vaccine

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In correspondence released in The New England Journal of Medicine, scientists from Massachusetts General Hospital keep in mind that Phase 3 medical information from the Moderna vaccine trial did reveal postponed skin hypersensitivity in a little number of the more than 30,000 trial individuals. However, the authors state the big, red, in some cases raised, scratchy or agonizing skin responses were never ever completely defined or described, and they alert clinicians might not be prepared to acknowledge them and guide clients on treatment choices and conclusion of the 2nd dosage of the vaccine. Credit: Massachusetts General Hospital

These responses need to not prevent clients from getting the vaccine, state scientists at Massachusetts General Hospital.

As the speed and scale of vaccinations versus the SARS-CoV-2 infection increases worldwide, scientists at Massachusetts General Hospital (MGH) are requiring higher awareness and interaction around a postponed injection-site response that can happen in some clients who have actually gotten the Moderna mRNA-1273 vaccine.

In a letter to the editor released online in The New England Journal of Medicine (NEJM), the authors note Phase 3 medical information from the Moderna vaccine trial did reveal postponed skin hypersensitivity in a little number of the more than 30,000 trial individuals. However, the authors state the big, red, in some cases raised, scratchy or agonizing skin responses were never ever completely defined or described, and they alert clinicians might not be prepared to acknowledge them and guide clients on treatment choices and conclusion of the 2nd dosage of the vaccine.

“Whether you’ve experienced a rash at the injection site right away or this delayed skin reaction, neither condition should prevent you from getting the second dose of the vaccine,” states Kimberly Blumenthal, MD, MSc, lead author of the letter and co-director of the Clinical Epidemiology Program in the department of Rheumatology, Allergy and Immunology at MGH. “Our immediate goal is to make physicians and other care providers aware of this possible delayed reaction, so they are not alarmed, but instead well-informed and equipped to advise their patients accordingly.”

In the letter, Blumenthal and her co-authors likewise note their own medical observations of the postponed, big, regional responses to the Moderna vaccine, and report on a series of 12 clients with the responses. In that group, sign beginning varied from 4 days after the very first dosage up to 11 days post-vaccination, with a mean beginning of signs on day 8. Photographs reveal the diverse size and intensity of the responses. Most clients were treated with ice and antihistamines, although some needed corticosteroids and one was mistakenly treated with prescription antibiotics.

“Delayed cutaneous hypersensitivity could be confused – by clinicians and patients alike – with a skin infection,” states letter co-author Erica Shenoy, MD, PhD, associate chief of the MGH Infection Control Unit. “These types of reactions, however, are not infectious and thus should not be treated with antibiotics.”

On average, signs cleaned up after almost a week for the group of 12 reported in the letter. Half of the clients went on to experience a response after the 2nd dosage – at or around 48 hours post-vaccination. No client experienced a dosage 2 response that was more serious than their dosage one response.

The authors likewise state samples drawn from skin biopsies validated their suspicion of a postponed allergic immune reaction that is frequently seen in drug responses.

“For most people who are experiencing this, we believe it’s tied to the body’s immune system going to work,” states Esther Freeman, MD, PhD, director of Global Health Dermatology at MGH and co-author of the NEJM letter. “Overall, this data is reassuring and should not discourage people from getting the vaccine.”

Reference: “Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2” by Kimberly G. Blumenthal, M.D.; Esther E. Freeman, M.D., Ph.D.; Rebecca R. Saff, M.D., Ph.D.; Lacey B. Robinson, M.D., M.P.H.; Anna R. Wolfson, M.D.; Ruth K. Foreman, M.D., Ph.D.; Dean Hashimoto, M.D.; Aleena Banerji, M.D.; Lily Li, M.D.; Sara Anvari, M.D. and Erica S. Shenoy, M.D., Ph.D., 3 March 2021, New England Journal of Medicine.
DOI: 10.1056/NEJMc2102131

To find out more about possibly allergies after COVID-19 vaccination, MGH Allergy is gathering all instant and postponed responses in a designated windows registry.

Additional co-authors of the NEJM letter were Aleena Banerji, MD, Ruth Foreman, MD, PhD, Dean Hashimoto, MD, Lacey Robinson, MD, Miles Per Hour, Rebecca Saff, MD, and Anna Wolfson, MD, all from MGH; Lily Li, MD, of Brigham and Women’s Hospital; and Sara Anvari, MD, MSc, Baylor College of Medicine, Texas Children’s Hospital.