Natural Compound Discovered With “Ideal” Contraceptive Effects

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Sperm Cell Illustration

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Dr Wei Yan found a natural substance that shows nearly perfect male contraceptive impacts in pre-clinical research studies.

In a paper released by Nature Communications, The Lundquist Institute (TLI) Investigator Wei Yan, MD, PhD, and his research study associates define an ingenious method that has actually resulted in the discovery of a natural substance as a safe, reliable, and reversible male contraceptive representative in pre-clinical animal designs. Despite remarkable efforts over the previous years, the development in establishing non-hormonal male contraceptives has actually been extremely restricted.

Wei Yan

Dr Wei Yan, Investigator, The LundquistInstitute Credit: The Lundquist Institute

The substance is triptonide, which can be either cleansed from a Chinese herb called Tripterygium Wilfordii Hook F, or produced through chemical synthesis. Single daily oral dosages of triptonide cause transformed sperm having very little or no forward motility with near 100% penetrance and subsequently male infertility in 3-4 and 5-6 weeks. Once the treatment is stopped, the males end up being fertile once again in ~ 4-6 weeks, and can produce healthy offspring. No discernable hazardous impacts were spotted in either brief- or long-lasting triptonide treatment. All of their information recommend that triptonide is an extremely appealing non-hormonal male contraceptive representative for guys due to the fact that it appears to satisfy all of the requirements for a practical contraceptive drug prospect, consisting of bioavailability, effectiveness, reversibility, and security. A battery of biochemical analyses recommend that triptonide targets among the last actions throughout sperm assembly, resulting in the production of transformed sperm without energetic motility needed for fertilization.

“Thanks to decades of basic research, which inspired us to develop the idea that a compound that targets a protein critical for the last several steps of sperm assembly would lead to the production of nonfunctional sperm without causing severe depletion of testicular cells,” statedDr Yan. “We are very excited that the new idea worked and that this compound appears to be an ideal male contraceptive. Our results using non-injurious studies on lower primates suggest triptonide will be an effective treatment for human males as well. Hopefully, we will be able to start human clinical trials soon to make the non-hormonal male contraceptive a reality.”

“Dr. Yan’s discovery represents a major leap forward in the field,” statedDrs Christina Wang and Ronald Swerdloff, who are TLI co-Principal Investigators assisting lead NIH-supported innovative scientific trials on hormone-based contraception methods. “The more contraceptive methods available, the better, as we will want a family of pharmaceutical products to safely and effectively meet the family planning needs of men and couples at different stages of their reproductive lives, with differing ethnic, cultural, and religious backgrounds and economic means,” highlighted Wang and Swerdloff.

Reference: “Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates” by Zongliang Chang, Weibing Qin, Huili Zheng, Kathleen Schegg, Lu Han, Xiaohua Liu, Yue Wang, Zhuqing Wang, Hayden McSwiggin, Hongying Peng, Shuiqiao Yuan, Jiabao Wu, Yongxia Wang, Shenghui Zhu, Yanjia Jiang, Hua Nie, Yuan Tang, Yu Zhou, Michael J. M. Hitchcock, Yunge Tang and Wei Yan, 23 February 2021, Nature Communications
DOI: 10.1038/ s41467-021-21517 -5

About The Lundquist Institute: Research with reach

The Lundquist Institute is an engine of development with an international reach and a 69- year track record of enhancing and conserving lives. With its brand-new medical research study structure, its cutting edge incubator, “BioLabs at The Lundquist,” existing lab and assistance facilities, and the advancement of a brand-new 15- acre service tech park, the Lundquist Institute acts as a center for the Los Angeles location’s growing biotech scene. The research study institute has more than 100 primary detectives (PhDs, MDs, and MD/PhDs) dealing with more than 600 research study studies, consisting of treatments for various, and typically deadly orphan illness.