One Shot of the Sputnik V COVID-19 Vaccine Triggers Strong Antibody Responses

Sputnik V Vaccine

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A single dosage of the Sputnik V vaccine might generate substantial antibody actions versus SARS-CoV-2, discovers a research study released on July 13, 2021, in the journal Cell Reports Medicine.

“Due to limited vaccine supply and uneven vaccine distribution in many regions of the world, health authorities urgently need data on the immune response to vaccines to optimize vaccination strategies,” states senior author Andrea Gamarnik (@GamarnikLaboratory) of the Fundación Instituto Leloir-CONICET in Buenos Aires, Argentina. “The peer-reviewed data we present provide information for guiding public health decisions in light of the current global health emergency.”

Past research study has actually revealed that 2 dosages of Sputnik V leads to 92% effectiveness versus coronavirus illness 2019 (COVID-19), which is triggered by SARS-CoV-2. An crucial concern is whether a single dosage would accomplish higher public health advantage than 2 dosages by permitting security of a bigger population faster.

Evidence from other vaccines uses assistance for the one-shot technique. The AstraZeneca vaccine programs 76% effectiveness after a single dosage, and the Moderna and Pfizer vaccines might cause adequate resistance in formerly contaminated people after one dosage, without any obvious advantage of an extra dosage.

Antibody Responses to Sputnik V Vaccine in Argentina

This visual abstract programs antibody actions to Sputnik V vaccine in Argentina. On the top, schematic representation of the two-component adenovirus based vaccine (rAD26 and rAD5) Sputnik V. Bottom, IgG antibody levels determined by International Units and SARS CoV-2 Neutralizing Titers in immunized ignorant (seronegative, blue) and formerly contaminated (seropositive, red) volunteers. There is a high seroconversion rate following the very first dosage in ignorant people. In formerly contaminated individuals, a single dosage of Sputnik V generates a quick and robust antibody action without obvious take advantage of a 2nd dosage. Credit: Rossi and Ojeda et al./Cell Reports Medicine

In the Cell Reports Medicine research study, Gamarnik and her associates compared the impacts of one and 2 shots of Sputnik V on SARS-CoV-2-specific antibody actions in 289 health care employees in Argentina. Three weeks after the 2nd dosage, all volunteers without any previous infection produced virus-specific immunoglobulin G (IgG) antibodies — the most typical kind of antibody discovered in blood.

But even within 3 weeks of getting the very first dosage, 94% of these individuals established IgG antibodies versus the infection, and 90% revealed proof of reducing the effects of antibodies, which disrupt the capability of infections to contaminate cells.

Additional results revealed that IgG and reducing the effects of antibody levels in formerly contaminated individuals were considerably greater after one dosage than those in totally immunized volunteers without any history of infection. A 2nd dosage did not increase the production of reducing the effects of antibodies in formerly contaminated volunteers.

“This highlights the robust response to vaccination of previously infected individuals, suggesting that naturally acquired immunity might be enhanced sufficiently by a single dose, in agreement with recent studies using mRNA vaccines,” Gamarnik states.

Further research studies are required to assess the period of the immune action and to evaluate how antibody levels associate with vaccine security versus COVID-19. “Evidence based on quantitative information will guide vaccine deployment strategies in the face of worldwide vaccine supply restriction,” Gamarnik states.

Reference: “Sputnik V Vaccine Elicits Seroconversion and Neutralizing Capacity to SARS CoV-2 after a Single Dose” by Andres H. Rossi, Ph.D.; Diego S. Ojeda, Ph.D.; Augusto Varese, Ph.D.; Lautaro Sanchez, M.Sc.; Maria M. Gonzalez Lopez Ledesma, Ph.D.; Ignacio Mazzitelli, M.D.; Anabel Alvarez Juliá, Ph.D.; Santiago Oviedo Rouco, Ph.D.; Horacio M. Pallarés, M.Sc.; Guadalupe S. Costa Navarro, M.Sc.; Natali Rasetto, M.Sc.; Corina I. Garcia, Ph.D.; Shirley D. Wenker, Ph.D.; Lila Y. Ramis, M.D.; Magalí G. Bialer, Ph.D.; Maria Jose de Leone, Ph.D.; C. Esteban Hernando, Ph.D.; Santiago Sosa, M.Sc.; Luciana Bianchimano, M.Sc.; Antonella Rios, M.Sc.; Maria Soledad Treffinger Cienfuegos, M.Sc.; Julio J. Caramelo, Ph.D.; Yesica Longueira, M.Sc.; Natalia Laufer, Ph.D.; Diego Alvarez, Ph.D.; Jorge Carradori, M.D.; Dariana Pedrozza, M.D.; Alejandra Rima, M.D.; Cecilia Echegoyen, M.D.; Regina Ercole, M.D.; Paula Gelpi, M.D.; Susana Marchetti, M.D.; Martín Zubieta, M.D.; Guillermo Docena, Ph.D.; Nicolas Kreplak, M.D.; Marcelo Yanovsky, Ph.D. and Jorge Geffne, 13 July 2021, Cell Reports Medicine.
DOI: 10.1016/j.xcrm.2021.100359

This work was supported by the National Institutes of Health (NIAID) and by the National Ministry of Science Technology and Innovation of Argentina.

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