Scientists discovered strong fixed electromagnetic fields can securely ease stress and anxiety and anxiety signs in mice. They think that high fixed electromagnetic fields have the prospective to be an antidepressant treatment in the future.
Scientists just recently performed a series of research studies to evaluate the biosafety and neurobehavioral results of 33.0 Tesla high fixed electromagnetic fields (SMF) utilizing the self-designed biological research study platform of Steady High Magnetic Field Facility (SHMFF). The experiments were carried out byProf Xin Zhang’s group at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences.
They, for the very first time, reported the biosafety of 30 Tesla level SMF and the neurobehavioral results of 20 Tesla and 30 Tesla level SMF on healthy mice in the Journal of Magnetic Resonance Imaging and European Radiology
In current years, ultra-high field magnetic resonance imaging (MRI) has actually established quickly due to its considerable benefit of high imaging resolution. 7 Tesla MRI has actually been scientifically authorized and 21.1 Tesla MRI has actually been effectively utilized in rodents. However, research studies on the biosafety of high electromagnetic fields above 20 Tesla are still limited, and there is still a space in pertinent research studies above 30 Tesla.
Based on the previous biosafety research study of 3.5-230 Tesla SMF, Xin Zhang’s group even more increased the electromagnetic field strength and reduced the direct exposure time. Healthy C57 BL/6J mice were exposed to 7.0-330 Tesla SMF for one hour.
Experiments performed on SHMFF. Credit: Yue Lyu
After direct exposure, all mice were regularly fed for 2 months. Except for a couple of metabolic and liver and hepatorenal function signs impacted by the electromagnetic field, the entire blood count and organ coefficient on histomorphology of primary organs were not seriously afflicted, Most of the mice stayed within the regular recommendation variety.
Meanwhile, behavioral tests revealed that high SMF minimized stress and anxiety and enhanced social and spatial memory in mice within 2 months after direct exposure.
In addition, behavioral research studies of healthy mice exposed to a 3.5-230 Tesla electromagnetic field for 2 hours likewise discovered enhanced neurocognitive results, which might be related to increased calcium/calmodulin-dependent protein kinase II expression in the mouse hippocampus.
Zhang’s group even more discovered that 7 Tesla SMF might efficiently ease signs of depressed mice. These results not just offer beneficial security details for the advancement of ultra-high MRI, however might likewise suggest that high SMF has the prospective to be a future antidepressant treatment.
Reference: “Short- and long-term effects of 3.5–23.0 Tesla ultra-high magnetic fields on mice behaviour” by Md Hasanuzzaman Khan, Xinfeng Huang, Xiaofei Tian, Changjie Ouyang, Dongmei Wang, Shuang Feng, Jutao Chen, Tian Xue, Jin Bao and Xin Zhang, 16 March 2022, European Radiology.
DOI: 10.1007/ s00330-022-08677 -8
This research study was supported by the National Key Research & & Development Program of Ministry of Science and Technology, the National Natural Science Foundation of China, the President’s Fund of Hefei Institutes of Physical Science, and so on
