Researchers found that supplementing a food regimen with the ocean organisms Ascidiacea, also called sea squirts, reverses among the important indicators of getting older in an animal mannequin.
Supplementing your food regimen with the ocean organisms Ascidiacea, also called sea squirts, reverses among the important indicators of getting older, in line with a brand new examine utilizing an animal mannequin.
While the Fountain of Youth, the legendary spring that restores youth to anybody who bathes in it or drinks its waters, is clearly fantasy, scientists are laborious at work searching for methods to fight getting older. Some of those scientists simply had a breakthrough: they found that supplementing a food regimen with sea squirts, reverses among the important indicators of getting older. While extra analysis is required to confirm the impact in people, because the examine was carried out utilizing mice, the findings are very promising.
If you’ve ever glanced within the mirror and seen greying hair and wrinkles, or when you’ve forgotten the title of a detailed buddy, it’s possible you’ll want a medicine which may halt and even reverse the results of getting older.
According to a brand new examine, this is probably not such a foolish thought. Researchers from Xi’an Jiaotong-Liverpool University, Stanford University, Shanghai Jiao tong University, and the University of Chinese Academy of Sciences found that supplementing a food regimen with the ocean organism Ascidiacea, also called sea squirts, reverses among the important indicators of getting older in an animal mannequin.
Sea squirts will be eaten uncooked and are present in dishes from Korea (the place it is named meongge, or 멍게) and Japan (hoya, or ホヤ). Credit: Jpatokal
Sea squirts could also be eaten uncooked and will be present in recipes from Korea (the place it is named meongge, or 멍게) and Japan (hoya, or ホヤ). These aquatic critters comprise plasmalogens, that are important to human physique processes. Plasmalogens are naturally discovered all through our our bodies, notably within the coronary heart, mind, and immune cells, however the amount in our our bodies declines as we age. This loss can also be a attribute of varied neurodegenerative illnesses, together with Alzheimer’s and Parkinson’s.
The researchers evaluated the effects of adding plasmalogens to the food of elderly mice to see whether increasing plasmalogen levels may prevent the effects of aging. They discovered that the supplements had a significant impact on the mice’s learning abilities and physical symptoms.
Professor Lei Fu, the corresponding author of the study, says: “Our research suggests that plasmalogens may not just stop cognitive decline, but may reverse cognitive impairments in the aging brain. Additionally, aged mice fed with the plasmalogens grow new black hair that is thicker and glossier than aged mice not fed the supplement.”
This study is the first to show, in detail, how plasmalogens affect the aging brain.
The sea organisms Ascidiacea, also called sea squirts, contain substances called plasmalogens, which are vital to our body processes. Credit: Prilfish
Making new connections
The effects of the plasmalogen supplement on learning and memory were evaluated by training mice to navigate a Morris water maze, which consists of a pool of water with a platform that acts as a resting place. Mice typically dislike swimming, so after five days of training, they remember where the platform is and swim directly to it as soon as they enter the pool. Older mice, on the other hand, take longer to locate the platform following the same amount of training.
Astonishingly, when fed with plasmalogens, aged mice perform more like young mice, finding the platform much quicker than the control group of aged mice that have not been given the supplement.
To find the reason for the improvement shown by plasmalogen-fed mice, the researchers took a closer look at changes happening within the brain. They found that mice that were fed the plasmalogen supplement had a higher number and quality of synapses – the connections between neurons – than the aged mice not given the supplements.
Aged mice showed improved learning and memory when fed with plasmalogen supplements from Ascidiacea – also known as sea squirts. In this study, mice were trained to find a hidden platform in a pool of water (Morris water maze), and the image shows the paths they took to reach the platform. After five days of training, young mice were able to remember the platform’s location, whereas aged mice took longer and swam further to reach the platform as they forgot its location. However, when fed a plasmalogen supplement, the aged mice took a shorter, quicker route to the platform than those not given the supplement – suggesting improved cognitive function. Credit: Lei Fu
Synapses are a fundamental part of our neural networks and, therefore, crucial for learning and memory. Our synapses tend to be very plastic as children, but they decrease in number and deteriorate with age and in neurogenerative diseases, resulting in cognitive impairments.
Accordingly, in this study, the aged mice fed with plasmalogen supplements showed greater potential for learning new skills and creating new neural networks than the aged mice whose diet was not supplemented. This suggests that dietary plasmalogens can halt the age-related deterioration of synapses.
A further characteristic of getting older, and thought to be a significant factor in neurodegeneration, is inflammation in the brain. Too much inflammation can have a negative effect on cognitive ability, as the brain’s immune system becomes overactive and turns on itself, attacking neurons and preventing synapses from functioning correctly.
In this study, the inflammation in aged mice was greatly decreased in those given plasmalogen supplements compared to those on a normal diet, providing some insight as to why they performed better in learning and memory tasks.
There are many varieties of sea squirts (Ascidiae). Some are shown in Ernst Haeckel’s Kunstformen der Natur (1904). Credit: Ernst Haeckel
Possible pathways of action
Although it is still unclear how dietary plasmalogen supplements seem to cause such significant changes in learning and memory, Professor Fu speculates on possible pathways of action.
“We found that plasmalogens significantly increase the number of molecules that aid the growth and development of neurons and synapses in the brain. This suggests that plasmalogens can promote neuroregeneration.
“There is also an increasing body of evidence that plasmalogens directly affect the structural properties of synapses. Plasmalogens may increase the fluidity and flexibility of synaptic membranes, affecting the transmission of impulses between neurons.”
Additionally, Professor Fu explains that plasmalogens may also have indirect effects on our brains.
“Some studies have shown that dietary plasmalogens affect the microorganisms in the gut. It has been widely reported that the connection between the organisms in our gut and our brain influences neurodegeneration. It may be the plasmalogen’s effect on this connection that causes the improvements in learning and memory are seen in this study.”
Professor Fu is so convinced by the results of this study that he takes a plasmalogen supplement each day.
“For the first time, we show that plasmalogen supplements might be a potential intervention strategy for halting neurodegeneration and promoting neuroregeneration.
“The oral intake of plasmalogens could be a feasible therapeutic strategy to improve cognitive function in older people.”
So, it could be that a pill to keep you young may not be such an unrealistic proposition after all – as long as it contains sea squirts.
Reference: “Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice” by Jinxin Gu, Lixue Chen, Ran Sun, Jie-Li Wang, Juntao Wang, Yingjun Lin, Shuwen Lei, Yang Zhang, Dan Lv, Faqin Jiang, Yuru Deng, James P. Collman and Lei Fu, 23 February 2022, Frontiers in Molecular Biosciences.
DOI: 10.3389/fmolb.2022.815320
