Understanding Astronaut Muscle Wasting at the Molecular Level

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Astronaut in Outer Space

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Researchers from the University of Tsukuba have actually sent out mice into area to check out impacts of spaceflight and lowered gravity on muscle atrophy, or losing at the molecular level.

Most people have actually envisioned how totally free it would feel to drift around, like an astronaut, in conditions of lowered gravity. But have you ever considered what the impacts of lowered gravity might have on muscles? Gravity is a consistent force on Earth which all living animals have actually progressed to depend on and adjust to. Space expedition has actually caused numerous clinical and technological advances, yet manned spaceflights come at an expense to astronauts, consisting of lowered skeletal muscle mass and strength.

Conventional research studies examining the impacts of lowered gravity on muscle mass and function have actually utilized a ground control group that is not straight similar to the area speculative group. Researchers from the University of Tsukuba set out to check out the impacts of gravity in mice subjected to the exact same real estate conditions, consisting of those experienced throughout launch and landing. “In humans, spaceflight causes muscle atrophy and can lead to serious medical problems after return to Earth,” states senior author Professor Satoru Takahashi. “This study was designed based on the critical need to understand the molecular mechanisms through which muscle atrophy occurs in conditions of microgravity and artificial gravity.”

Two groups of mice (6 per group) were housed onboard the International Space Station for 35 days. One group underwent synthetic gravity (1 g) and the other to microgravity. All mice lived upon go back to Earth and the group compared the impacts of the various onboard environments on skeletal muscles.

“To understand what was happening inside the muscles and cells, at the molecular level, we examined the muscle fibers. Our results show that artificial gravity prevents the changes observed in mice subjected to microgravity, including muscle atrophy and changes in gene expression,” described Prof. Takahashi. Transcriptional analysis of gene expression exposed that synthetic gravity avoided modified expression of atrophy associated genes and determined unique prospect genes related to atrophy. Specifically, a gene called Cacng1 was determined as potentially having a practical function in myotube atrophy.

This work supports using spaceflight datasets utilizing 1 g synthetic gravity for analyzing the impacts of spaceflight in muscles. These research studies will likely assist our understanding of the systems of muscle atrophy and might eventually affect the treatment of associated illness.

Reference: “Transcriptome analysis of gravitational impacts on mouse skeletal muscles under microgravity and synthetic 1 g onboard environment” by Risa Okada, Shin-ichiro Fujita, Riku Suzuki, Takuto Hayashi, Hirona Tsubouchi, Chihiro Kato, Shunya Sadaki, Maho Kanai, Sayaka Fuseya, Yuri Inoue, Hyojung Jeon, Michito Hamada, Akihiro Kuno, Akiko Ishii, Akira Tamaoka, Jun Tanihata, Naoki Ito, Dai Shiba, Masaki Shirakawa, Masafumi Muratani, Takashi Kudo and Satoru Takahashi, 28 April 2021, Scientific Reports.
DOI: 10.1038/s41598-021-88392-4



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