Researchers have actually found that specific fats collect in tissues with age however can be decreased through routine workout. This finding, which sheds brand-new light on the biological procedures of aging, was originated from research studies performed on both mice and people, stressing the capacity for brand-new aging interventions.
Scientists have actually discovered that a particular sort of fat develop in tissues as they age, which workout can reverse this procedure. A group from Amsterdam UMC, in cooperation with scientists from Maastricht UMC+, studied tissue from both mice and people before and after workout to reach this conclusion.
The outcomes were just recently released in the journal Nature Aging
“The idea that we could reverse aging is something that was long considered science fiction, but these findings do allow us to understand a lot more about the aging process,” states Riekelt Houtkooper, Professor at the lab Genetic Metabolic Diseases of Amsterdam UMC. “Everyone says that ‘it’s just part of getting older,’ but this doesn’t actually have to be true. By understanding more about the aging process, we can also look into new ways of intervening,” states Georges Janssens, very first author of the paper and assistant teacher at Amsterdam UMC.
Research on Age-Related Diseases
In current years, lab research study has actually revealed that we might have the ability to combat age-related illness by intervening in the basic procedures that result in aging. Although science has actually significantly drawn up how metabolic process modifications throughout aging, big parts stayed uncharted. “We wanted to add a new chapter to the atlas. Lipids are an important part of our diet, and crucial for the functioning of our body cells. Specific lipids make up the membrane of cells, which ensures that the inside and outside remain separate,” states Houtkooper.
In order to include this brand-new chapter, the research study group examined how the structure of fats modifications in mice. They took a look at 10 various tissues, consisting of muscles, kidneys, liver, and heart. It was observed that a person kind of lipid, the bis( monoacylglycero) phosphates (or BMPs), rose in all tissues from the older animals. Suggesting a build-up of these lipids throughout aging. They then examined whether this likewise takes place in people. Although it was not possible to get as various tissues, the build-up of BMP was likewise noticeable in muscle biopsies of older individuals. Finally, they then finished more muscle biopsies from individuals before and after a healthy intervention that consisted of one hour of workout a day and saw the level of BMPs reduced in the active individuals.
“These results are an important new step for our understanding of the aging process, but they are certainly not the final answer. We plan to conduct follow-up studies to better understand how BMPs contribute to aging, what are the consequences of BMP accumulation on the aging process, and whether this can only be influenced by exercise or are the other ways to affect BMPs levels,” concludes Houtkooper.
Reference: “A conserved complex lipid signature marks human muscle aging and responds to short-term exercise” by Georges E. Janssens, Marte Molenaars, Katharina Herzog, Lotte Grevendonk, Carlijn M. E. Remie, Martin A. T. Vervaart, Hyung L. Elfrink, Eric J. M. Wever, Bauke V. Schomakers, Simone W. Denis, Hans R. Waterham, Mia L. Pras-Raves, Michel van Weeghel, Antoine H. C. van Kampen, Alessandra Tammaro, Loes M. Butter, Sanne van der Rijt, Sandrine Florquin, Aldo Jongejan, Perry D. Moerland, Joris Hoeks, Patrick Schrauwen, Fr édéric M. Vaz and Riekelt H. Houtkooper, 12 April 2024, Nature Aging
DOI: 10.1038/ s43587-024-00595 -2
