Schematic illustration revealing the function of GQDs, stemmed from erythrocyte membranes, as peroxidase– imitate enzyme for growth catalytic treatment. Credit: FHIPS
A group led by Professor Wang Hui at the Hefei Institutes of Physical Science, part of the Chinese Academy of Sciences, has actually established a metal-free nanozyme utilizing < period class ="glossaryLink" aria-describedby ="tt" data-cmtooltip ="<div class=glossaryItemTitle>graphene</div><div class=glossaryItemBody>Graphene is an allotrope of carbon in the form of a single layer of atoms in a two-dimensional hexagonal lattice in which one atom forms each vertex. It is the basic structural element of other allotropes of carbon, including graphite, charcoal, carbon nanotubes, and fullerenes. In proportion to its thickness, it is about 100 times stronger than the strongest steel.</div>" data-gt-translate-attributes ="[{"attribute":"data-cmtooltip", "format":"html"}]" tabindex ="0" function ="link" > graphene quantum dots( GQDs).(***************************************************************** )development is targeted at boosting the efficiency of growth chemodynamic treatment (CDT).
The research study was released in the journalMatter
GQDs represent an appealing and cost-efficient methods of resolving the toxicity issues connected with metal-based nanozymes in growth CDT.However, the minimal catalytic activity of GQDs has actually postured substantial obstacles for their medical application, especially under difficult catalytic conditions.
“The obtained GQDs, which are made from red blood cell membranes, are highly effective in treating tumors with few side effects,” stated LIU Hongji, a member of the research study group. “One of the advantages is that they are metal-free. In addition, they function as excellent peroxidase-like biocatalysts.”
Enhancing Catalytic Performance
To improve the catalytic efficiency of the GQD-based nanocatalytic adjuvant, the scientists reasonably developed GQDs utilizing a diatomic doping method. The synergistic electron result of presenting nitrogen and phosphorus into GQDs can create extremely localized states near the Fermi level, therefore making it possible for effective enzymatic activity compared to single heteroatom doping.
The acquired GQDs, stemmed from erythrocyte membranes, have actually been revealed to have excellent peroxidase-mimicking activity. As an outcome, the GQDs are extremely efficient at causing apoptosis and ferroptosis of cancer cells in vitro They likewise selectively target growths, with a growth inhibition rate as high as 77.71% for intravenous injection and 93.22% for intratumoral injection, without any off-target negative effects.
This drug-free, target-specific, and biologically benign nanozyme has fantastic possible as a powerful biocatalyst for usage in safe cancer treatment.
Reference: “Graphene quantum dots as metal-free nanozymes for chemodynamic therapy of cancer” by Hongji Liu, Zhiming Deng, Zonghui Zhang, Wenchu Lin, Miqin Zhang and Hui Wang, 10 January 2024, Matter
DOI: 10.1016/ j.matt.202312005
