A brand new examine from the University of Eastern Finland has discovered that consumption of fatty fish lowers the lipophilic index, indicative of improved cell membrane fluidity, in people with impaired glucose metabolism or coronary coronary heart illness. This decrease lipophilic index, linked to bigger HDL particles and diminished cardiovascular threat, was not seen in individuals consuming lean fish or camelina sativa oil.
A latest examine performed by the University of Eastern Finland has found that consuming fatty fish can decrease the lipophilic index in people with impaired glucose metabolism or coronary coronary heart illness.
The lipophilic index is an indicator of the fluidity of cell membranes. The decrease the lipophilic index, the higher the membrane fluidity. This newest examine, revealed in Nutrition, Metabolism & Cardiovascular Diseases, additionally linked a diminished lipophilic index with an elevated imply measurement of HDL particles and a better focus of bigger HDL particles, which suggests cardiovascular profit.
The lipophilic index has been launched to explain membrane fluidity, which may modify the perform of cells and membrane-bound proteins. The size and saturation of fatty acids in membranes have an effect on membrane fluidity. For instance, fatty acids in serum lipids or erythrocyte membranes can be utilized to calculate the lipophilic index.
Previous research have prompt that long-chain omega-Three fatty acids in fish have a helpful impact on cardiovascular threat, nevertheless, extra analysis into the mechanisms remains to be wanted. Camelina oil, however, is wealthy in alpha-linolenic acid, which is an essential omega-3 fatty acid whose associations with membrane fluidity are not known.
The researchers used data from two randomized clinical trials to study the effects of fish and camelina sativa oil intake on the lipophilic index. The first study included 79 men and women with impaired glucose tolerance. The second study included 33 men and women with cardiovascular disease.
Study participants were randomly divided into four groups for a 12-week intervention: the camelina oil group, the fatty fish group, the lean fish group, and the control group in the first study. In the second study, subjects were randomly divided into fatty fish, lean fish, and control groups for an 8-week intervention. The lipophilic index was calculated based on erythrocyte membrane fatty acids in the first study, and serum phospholipid fatty acids in the second study.
In both studies, eating four meals of fatty fish per week reduced the lipophilic index, which indicates better membrane fluidity. Better membrane fluidity has been associated with lower cardiovascular risk. Better membrane fluidity as measured by the lipophilic index was also associated with larger HDL particles, which have also been associated with a lower cardiovascular risk. Eating lean fish or camelina sativa oil did not affect the lipophilic index.
Reference: “Fatty fish consumption reduces lipophilic index in erythrocyte membranes and serum phospholipids” by Arja T. Lyytinen, Monira Yesmean, Suvi Manninen, Maria Lankinen, Monika Bhalke, Linda Fredrikson, Reijo T. Käkelä, Katariina Öörni and Ursula S. Schwab, 17 April 2023, Nutrition, Metabolism and Cardiovascular Diseases.
DOI: 10.1016/j.numecd.2023.04.011
