Alcohol Changes Brain Activity Differently in Males and Females

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Alcohol usage is likewise carefully associated with state of mind conditions such as extreme anxiety and generalized stress and anxiety condition.

Alcohol changes anxiety-related integrated brain activity.

According to a current research study released in the journal eNeuro, alcohol alters the integrated brain activity in the amygdala of mice, however in a different way for male and female mice.

Alcoholism is typically connected with stress and anxiety and unhappiness, and a brain location called the amygdala is linked in both. Both rodents and human beings are vulnerable to the impacts of oscillations, or shifts in integrated brain activity, in between areas like the amygdala and prefrontal cortex. It is unidentified, nevertheless, how alcohol might impact the amygdala network and impact habits.

Alcohol Mice

Alcohol changes amygdala activity in a different way in male and female mice. Credit: DiLeo et al., eNeuro 2022

Alyssa DiLeo and her group administered alcohol to mice and determined matching modifications in oscillatory states in the amygdala. Alcohol impacted amygdala oscillations in a different way in male and female mice, specifically after repetitive alcohol administration. In reality, the oscillatory state of women did not alter at all after repetitive alcohol administration.

The scientists duplicated the experiment in mice without a subunit of a receptor connected to alcohol usage and stress and anxiety, which caused qualities of the female network activity in males. These results show alcohol can set off the amygdala to change activity states, which might drive modifications in nervous and afraid habits.

Reference: “Sex Differences in the Alcohol-Mediated Modulation of BLA Network States” by Alyssa DiLeo, Pantelis Antonoudiou, Spencer Ha and Jamie L. Maguire, 4 July 2022, eNeuro.
DOI: 10.1523/ ENEURO.0010-222022

The research study was moneyed by the National Institutes of Health.