New Imaging Technology Provides a Quick Look Inside a Human Being

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Researchers from the Julius-Maximilians-Universität Würzburg (JMU) have developed a transportable, radiation-free scanner utilizing Magnetic Particle Imaging (MPI). This approach, able to visualizing dynamic processes like blood circulate within the human physique, is predicated on the detection of magnetic nanoparticles administered as markers.

Technologies like computed tomography, magnetic resonance imaging, positron emission tomography, and ultrasound at the moment are integral elements of the medical area, providing unique insights into human anatomy. These methods not solely present detailed imaging of the human physique but in addition assist physicians determine abnormalities or analyze practical processes inside.

A bunch comprising physicists and medical consultants from Julius-Maximilians-Universität Würzburg (JMU) has efficiently developed an modern, radiation-free imaging approach that’s appropriate for human use known as Magnetic Particle Imaging (MPI). Their newly invented transportable scanner is able to, amongst different issues, visualizing dynamic processes within the human physique, comparable to blood circulate.

Professor Volker Behr and Dr. Patrick Vogel from the University’s Institute of Physics are accountable for this research; they’ve now revealed the ends in the journal Nature Scientific Reports.

A sensitive and fast alternative

Magnetic particle imaging is a technique based, as the name suggests, on the direct visualization of magnetic nanoparticles. Such nanoparticles do not occur naturally in the human body and must be administered as markers. “As with positron emission tomography, which relies on the administration of radioactive substances as markers, this method has the great advantage of being sensitive and fast without ‘seeing’ interfering background signals from tissue or bone,” explains Volker Behr.

The iMPI Scanner

The iMPI scanner is so small and light that you can take it with you and use it almost anywhere. This is a first important step towards radiation-free intervention. Credit: Patrick Vogel / Stefan Herz

MPI is not based on the detection of gamma rays from a radioactive marker like positron emission tomography but on the response signal of the magnetic nanoparticles to magnetic fields that change over time.

“In this process, the magnetization of nanoparticles is specifically manipulated with the help of external magnetic fields, whereby not only their presence but also their spatial position in the human body can be detected,” says physicist Patrick Vogel, first author of the publication.

A small scanner for big insights

The MPI idea is not new. As early as 2005, the Philips company was able to show the first images of this novel approach in a small demonstrator, which, however, could only take samples a few centimeters in size. And the development of devices suitable for examining humans proved more difficult than expected, leading to large, heavy and expensive constructions.

In 2018, the team led by Professor Volker Behr and Patrick Vogel found a new way to implement the complex magnetic fields required for imaging in a much smaller design. In a multi-year research project funded by the German Research Foundation (DFG), the scientists succeeded in implementing the novel concept in an MPI scanner (interventional Magnetic Particle Imaging – iMPI) specifically designed for intervention.

“Our iMPI scanner is so small and light that you can take it almost anywhere,” Vogel explains. The authors impressively demonstrate this mobility of the scanner in a simultaneous real-time measurement in comparison with a special X-ray device, which is the standard device in angiography in university hospitals. The team led by Professor Thorsten Bley and Dr. Stefan Herz of the Interventional Radiology Department of the Würzburg University Hospital, which accompanied this project from the beginning, carried out the measurements on a realistic vascular phantom and evaluated the first images.

“This is a first important step towards radiation-free intervention. MPI has the potential to change this field for good,” said Dr. Stefan Herz, senior author of the publication.

Next steps in research

In addition to further exciting measurements with the iMPI device, the two physicists are now working on further developing their scanner. The main goal is to further improve the image quality.

Reference: “iMPI: portable human-sized magnetic particle imaging scanner for real-time endovascular interventions” by P. Vogel, M. A. Rückert, C. Greiner, J. Günther, T. Reichl, T. Kampf, T. A. Bley, V. C. Behr and S. Herz, 28 June 2023, Scientific Reports.
DOI: 10.1038/s41598-023-37351-2